Prevention, intervention, and management of physical training in the rehabilitation of lower limb injuries / Prevenção, intervenção e gerenciamento do treinamento físico na reabilitação de lesões nos membros inferiores / Prevención, intervención y gestión del entrenamiento físico en la rehabilitación de lesiones de los miembros inferiores

ABSTRACT Introduction Lower limb injuries are one of the main sports occurrences among athletes. Severe lower limb injuries will lead to the definitive end of the athlete's professional career. Objective Explore the mechanisms of prevention and intervention against lower limb injuries in physical training and the rehabilitation management strategies for lower limb injuries. Methods In this study, 20 athletes were selected. Comparing the results of the lower limb FMS test and balance y test before and after rehabilitation training management, the effect of rehabilitation management on recovery from lower limb injuries in physical training was discussed. Results Lower limb injury is a common type of sports injury in physical training; however, better recovery utilization can be achieved through successful rehabilitation training. Rehabilitation training management can effectively improve the FMS test score of athletes' lower limbs and the number of people who passed the Y balance test. However, the existing rehabilitation training program still has some limitations, which need to be corrected according to the individual conditions of athletes. Conclusion Through physical training and medical rehabilitation, athletes with lower limb injuries can recover their lower limb sports ability and prolong their sporting life. Therefore, it should be disseminated. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução A lesão nos membros inferiores é uma das principais ocorrências esportivas entre os atletas. Lesões graves nos membros inferiores levarão ao encerramento definitivo da carreira profissional do atleta. Objetivo Explorar os mecanismos de prevenção e intervenção contra lesões dos membros inferiores no treinamento físico e as estratégias de gerenciamento de reabilitação para lesões dos membros inferiores. Métodos Neste trabalho, 20 atletas foram selecionados. Por meio da comparação dos resultados do teste FMS de membros inferiores e do teste de equilíbrio y antes e depois do gerenciamento do treinamento de reabilitação, foi discutido o efeito do gerenciamento de reabilitação na recuperação de lesões dos membros inferiores no treinamento físico. Resultados A lesão dos membros inferiores é um tipo corriqueiro de lesão esportiva no treinamento físico, porém um melhor aproveitamento da recuperação pode ser alcançado através de um treinamento de reabilitação bem-sucedido. O gerenciamento do treinamento de reabilitação pode efetivamente melhorar a pontuação do teste FMS dos membros inferiores dos atletas e o número de pessoas que passaram no teste de equilíbrio Y. Entretanto, o programa de treinamento de reabilitação existente ainda apresenta algumas limitações, que precisam ser corrigidas de acordo com as condições individuais dos atletas. Conclusão Através da combinação de treinamento físico e reabilitação médica, os atletas com lesão nos membros inferiores podem recuperar sua capacidade esportiva nos membros inferiores e prolongar uma vida esportiva. Portanto, convém difundi-lo. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción Las lesiones en los miembros inferiores son uno de los principales sucesos deportivos entre los atletas. Las lesiones graves en los miembros inferiores conducirán al final definitivo de la carrera profesional del atleta. Objetivo Explorar los mecanismos de prevención e intervención contra las lesiones de los miembros inferiores en el entrenamiento físico, y las estrategias de gestión de la rehabilitación de las lesiones de los miembros inferiores. Métodos En este estudio se seleccionaron 20 atletas. Mediante la comparación de los resultados de la prueba de FMS de las extremidades inferiores y la prueba de equilibrio y antes y después de la gestión del entrenamiento de rehabilitación, se analizó el efecto de la gestión de la rehabilitación en la recuperación de las lesiones de las extremidades inferiores en el entrenamiento físico. Resultados Las lesiones en las extremidades inferiores son un tipo de lesión deportiva común en el entrenamiento físico, sin embargo, se puede lograr una mejor utilización de la recuperación mediante un entrenamiento de rehabilitación exitoso. La gestión del entrenamiento de rehabilitación puede mejorar eficazmente las puntuaciones de los atletas en las pruebas de FMS de las extremidades inferiores y el número de personas que superan la prueba de equilibrio Y. Sin embargo, el programa de entrenamiento de rehabilitación existente sigue teniendo algunas limitaciones, que deben corregirse en función de las condiciones individuales de los deportistas. Conclusión Mediante la combinación de entrenamiento físico y rehabilitación médica, los atletas con lesiones en las extremidades inferiores pueden recuperar su capacidad deportiva y prolongar su vida deportiva. Por lo tanto, debe difundirse. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Gut-derived lipopolysaccharide promotes alcoholic hepatosteatosis and subsequent hepatocellular carcinoma by stimulating neutrophil extracellular traps through toll-like receptor 4

Background/Aims@#Binge drinking leads to many disorders, including alcoholic hepatosteatosis, which is characterized by intrahepatic neutrophil infiltration and increases the risk of hepatocellular carcinoma (HCC). Molecular mechanisms may involve the migration of bacterial metabolites from the gut to the liver and the activation of neutrophil extracellular traps (NETs). @*Methods@#Serum samples from both binge drinking and alcohol-avoiding patients were analyzed. Mouse models of chronic plus binge alcohol-induced hepatosteatosis and HCC models were used. @*Results@#A marker of NETs formation, lipopolysaccharide (LPS), was significantly higher in alcoholic hepatosteatosis and HCC patients and mice than in controls. Intrahepatic inflammation markers and HCC-related cytokines were decreased in mice with reduced NET formation due to neutrophil elastase (NE) deletion, and liver-related symptoms of alcohol were also alleviated in NE knockout mice. Removal of intestinal bacteria with antibiotics led to decreases in markers of NETs formation and inflammatory cytokines upon chronic alcohol consumption, and development of alcoholic hepatosteatosis and HCC was also attenuated. These functions were restored upon supplementation with the bacterial product LPS. When mice lacking toll-like receptor 4 (TLR4) received chronic alcohol feeding, intrahepatic markers of NETs formation decreased, and hepatosteatosis and HCC were alleviated. @*Conclusions@#Formation of NETs following LPS stimulation of TLR4 upon chronic alcohol use leads to increased alcoholic steatosis and subsequent HCC.

Expression of AQP5 in colorectal cancer and its relationship with clinical outcome / 西安交通大学学报(医学版)

Objective To determine the relationship of the expression of aquaporin 5 (AQP5)with clinicopathology and prognosis of colorectal cancer.Methods We collected data from 45 patients with primary colorectal cancer without any adjuvant therapy before operation.The expression of AQP5 was measured by immunohistochemistry (IHC).Then we analyzed the correlation between AQP5 expression and clinicopathological parameters (including age,tumor size,clinical staging,tumor location,lymph node and pathological type)and the connection between AQP5 expression and prognosis based on follow-up data.Results Of the 45 tumor specimens,14 (31.1%)had a high level of AQP5 expression,29 (64.4%)exhibited a moderate level of staining,and 2 (4.4%)had an absence of AQP5 staining.AQP5 was only occasionally detected in para-neoplastic [3/45 (6.67%)]and normal tissues [3/45 (6.67%)].The overexpression of AQP5 was also positively associated with TNM stage (P =0.002),lymph node metastasis (P =0.01 6),and distant metastasis (P =0.000).However,it had no significant association with age, gender,histologic grade or tumor size (P > 0.05 ).Conclusion AQP5 may be used as a novel biomarker for predicting the prognosis of colorectal cancer.

Splenic macrophage phagocytosis and hypersplenism in cirrhotic portal hypertensive patients / 中国普通外科杂志

Objective To study the correlation between splenic macrophage (M?) phagocytosis and peripheral blood cell count in cirrhotic portal hypertensive (CPH) patients Methods Spleen M? phagocytosis was measured in 20 CPH patients with hypersplenism and 6 patients with traumatic spleen rupture Results The M? phagocytosis rate in CPH patients was (12 6?3 0)% compared with (6 9?0 5)% in traumatic patients ( P

THE BEHAVIOR OF LYMPHATIC METASTASIS OF WALKER CARCINOSARCOMA 256 IN RATS / 解剖学报

Walker carcinosarcoma 256 cells were injected intradermally into the medialaspect of right footpad of rats.After injection,the drained lymph nodes and overthe area of route of entry were examined microscopically in different period,inorder to determine the positive rate of appearance of cancer cells and metastasis inlymph nodes as well as other pathological changes.In the local area of inoculation cancer cells were noticed passing through spacesbetween the endothelial cells by ameboid movement into capillary lymph-vessels ormoved along with the lymph stream and get in to the capillary lymph-vessels fromtheir open ends.Individual or clumped cancer cells were seen in lymph-vesselsunder the epithelium and in the afferent lymph-vessels of lymph nodes.One hourafter the injection individual cancer cells were found first in the popliteal lymph nodes,then in the lumbar or renal lymph nodes on the third day.These cancer cellsappeared in the subcapsular sinuses at first,then in the intermediate and medullarysinuses subsequently and might be passed from one lymph node to another throughthe efferent lymph-vessels,for instance,cancer cells in popliteal nodes might migrateto lumbal or renal lymph nodes.When the cancer cells in lymph nodes became amass of a certain size associating with mitotic figures,a metastatic focus was thenestablished.Within twelve days after the inoculation,the total positive rates ofcancer cells and metastasis present in the popliteal lymph nodes were 59.5% and thetotal positive rate of multiple metastasis present simultaneously in several lymphnodes was 18.9 per sent.In addition to metastasis,these lymph nodes showed also themselves some im-mune changes,as including proliferation and enlargement of lymph follicles in cortex;widening of the paracortical area;ameboid movement present in different forms ofsmall lymphocytes and reticulosis,transformation of plasmacytes as well as increaseof immunoblasts.